交叉學科
于煒婷
基本情況：
于煒婷，女，大連大學附屬中山醫(yī)院研究員，碩士生導師，人才學科建設部部長。
2018年榮獲遼寧省“百千萬人才工程”百層次人選（遼人社[2018]62號）
2019年入選遼寧省高等學校創(chuàng)新人才計劃
2019年度獲批大連市本地全職高層次人才（高端人才）。
簡歷介紹：
從事海洋多糖水凝膠生物材料及其在生物醫(yī)學領域應用研究20余年。主持多項國家基金委、科技部“973”子課題、重大新藥創(chuàng)制專項子課題、國家重點研發(fā)計劃“干細胞及轉(zhuǎn)化研究”專項子課題等國家級課題；主持國家海洋局海洋公益課題、遼寧省重點研發(fā)計劃項目各一項；主持省市級科技計劃課題7項，企業(yè)橫向項目2項。通訊及一作發(fā)表論文39篇（其中SCI收錄28篇，多篇發(fā)表在ACS Applied Materials & Interfaces，Chemical Communications，Journal of Membrane Science, Carbohydrate Polymers等JCR一區(qū)或二區(qū)期刊上）；主編著作《海藻酸基海洋生物醫(yī)用材料》，獲國家出版基金項目資助，《“十三五”國家重點圖書、音像、電子出版物出版規(guī)劃》立項。授權國際專利3項，中國發(fā)明專利40項。與“海洋多糖生物醫(yī)用材料技術”相關成果以無形資產(chǎn)（評估1700萬）增資到中科院大連化學物理研究所張家港產(chǎn)業(yè)技術研究院有限公司。作為主要完成人參與的“超純海藻酸鹽材料制備技術”研究成果在青島明月集團完成中試和成果轉(zhuǎn)化。獲得省部級一等獎2項、二等獎1項、市級一等獎1項。
在研主持課題情況：
[1] 遼寧省重點研發(fā)計劃項目：多孔鎂-水凝膠多層仿生支架一體化修復大面積軟骨及軟骨下骨缺損的研究（2020JH2/10300093），2020/05至2022/04，30萬元，項目負責人，項目批準單位：遼寧省科技廳。
[2] 遼寧省“百千萬人才工程”資助項目：微環(huán)境仿生構(gòu)建及其調(diào)控干細胞成骨、成軟骨分化的研究（遼人社[2019]45號），2萬元，項目負責人，項目批準單位：遼寧省人力資源和社會保障廳。
[3] 國家重點研發(fā)計劃“干細胞及轉(zhuǎn)化研究”專項課題：干細胞在生物反應器中的規(guī)模化培養(yǎng)和適應性調(diào)控（2018YFA0108203），2018.07-2022.12，794萬，子課題“干細胞在生物反應器中的規(guī)模化培養(yǎng)研究”負責人，可支配經(jīng)費120萬，項目批準單位：國家科技部
社會兼職及榮譽：
大連市醫(yī)學會醫(yī)學工程專科分會副主任委員(2021.07-2024.07)
招聘博士后的專業(yè)方向要求：
1. 腫瘤類器官的工程化構(gòu)建研究；
2. 軟組織工程研究；
3. 藥物緩控釋載體研究。
代表性研究成果：
[1] Liu XD, Zhou HF, Yu WT*, Xiong X, Krastev R, Ma XJ. Preparation of Cationic Amphiphilic Nanoparticles with Modified Chitosan Derivatives for Doxorubicin Delivery. Materials 2021, 14, 7010
[2] Zheng GS, Liu XD, Hu MH, Zhao DW*, Yu WT*. Two types of polyelectrolyte multilayers hydrogel membrane based on chitosan and alginate with different self-assembled process for control L929 cell behavior. International Journal of Biological Macromolecules, 2019, 140: 1134–1146
[3] Rong JJ, Liang M, Xuan FQ, Sun JY, Zhao LJ, Zhen HZ, Tian XX, Liu D, Zhang QY, Peng CF, Li F, Wang XZ, Han YL*, Yu WT*. Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization. International Journal of Biological Macromolecules, 2017, 104: 1302-1312
[4] Lou RY, Yu WT*, Song YZ, Ren Y, Zheng HZ, Guo X, Lin YF, Pan GY, Wang XL*, Ma XJ. Fabrication of stable galactosylated alginate microcapsules via covalent coupling onto hydroxyl groups for hepatocytes applications. Carbohydrate Polymers, 2017, 155: 456-465
[5] Zheng HZ, Gao M, Ren Y,Lou RY,Xie HG, Yu WT*, Liu XD*, Ma XJ. An improved pH-responsive carrier based on EDTA-Ca-Alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103. Carbohydrate Polymers, 2017, 155: 329-335
[6] Zheng HZ, Gao M, Ren Y,Lou RY,Xie HG, Yu WT*, Liu XD*, Ma XJ. Controlling gel structure to modulate cell adhesion and spreading on the surface of microcapsules. ACS Applied Materials & Interfaces, 2016, 8 (30): 19333–19342
[7] Ren Y, Lou RY, Liu XC, GaoM, Zheng HZ, Yang T, Xie H*, Yu WT*, Ma XJ. Tuning the formation and stability of microcapsules by environmental conditions and chitosan structure. International Journal of Biological Macromolecules, 2016, 91: 1090-1100
[8] Lou RY, Xie HG, Zheng HZ, Ren Y,Gao M, Guo X, Song YZ, Yu WT*, Liu XD*, Ma XJ. Alginate-based microcapsules with galactosylated chitosan internal for primary hepatocyte applications. International Journal of Biological Macromolecules, 2016, 93PA: 1133-1140
[9] Ren Y, Lou RY, Liu XC, Gao M, Zheng HZ, Yang T, Xie HG*,Yu WT*, Ma XJ. A self-healing hydrogel formation strategy via exploiting endothermic interactions between polyelectrolytes. Chemical Communications, 2016, 52: 6273-6276
[10] Song YZ, Zhang DM, Lv Y, Guo X, Lou RY, Wang SJ, Wang XL*, Yu WT*, Ma XJ. Microfabrication of a tunable collagen/alginate-chitosan hydrogel membrane for controlling cell-cell interactions. Carbohydrate Polymers, 2016, 153: 652-662.
[11] Ren Y, Xie HG*, Liu XD, Bao J, Yu WT*, Ma XJ. Comparative investigation of the binding characteristics of poly-l-lysine and chitosan on alginate hydrogel. International Journal of Biological Macromolecules, 2016, 84: 135-141
[12] GaoM, Song HY,Zheng HZ, Ren Y, Li S,Liu XD*,Yu WT*, MaXJ. Culture of low density E. coli cells in alginate–chitosan microcapsules facilitates stress resistance by up-regulating luxS/AI-2 system. Carbohydrate Polymers, 2016, 141: 160-165
[13] Gao M, Zheng HZ, Ren Y, Lou RY, Wu F, Yu WT*, Liu XD*, Ma XJ. A crucial role for spatial distribution in bacterial quorum sensing. Scientific Reports, 2016, 6:34695
[14] Zheng GS, Zheng HZ,Xie HG, Liu XD*,Yu WT*, Ma XJ. The cause and influence of sequentially assembling higher and lower deacetylatedchitosans on the membrane formation of microcapsule. Journal of Biomedical Materials Research: Part A, 2016, 104 (1):257-263
[15] Rong JJ, Liang M, Xuan FQ, Sun JY, Zhao LJ, Zhen HZ, Tian XX, Liu D, Zhang QY, Peng CF,Yao TM, Li F, Wang XZ, Han YL*, Yu WT*. Alginate-calcium microsphere loaded with thrombin: a new composite biomaterial for hemostatic embolization. International Journal of Biological Macromolecules, 2015, 75:479–488
[16] Zheng GS, Liu XD, Wang XL, Chen L, Xie HG, Wang F, Zheng HZ,Yu WT*, Ma XJ*. Improving Stability and Biocompatibility of Alginate/Chitosan Microcapsule by Fabricating Bi-Functional Membrane. Macromolecular Bioscience, 2014, 14(5): 655-66
[17] Song HY, Yu WT*,Liu XD, Ma XJ*, Improved probiotic viability in stress environments with post-culture of microencapsulated low density cells, Carbohydrate Polymers, 2014, 108: 10-16
[18] Song HY, Yu WT*, Gao M, Liu XD*, Ma XJ, Microencapsulated probiotics using emulsification technique coupled with internal or external gelation process, Carbohydrate Polymers, 2013, 96:181-189
[19] Yu WT, Song HY, Zheng GS, Liu XD, Zhang Y, Ma XJ, Study on membrane characteristics of alginate-chitosan microcapsule with cell growth, Journal of Membrane Science, 2011, 377(1-2): 214-220
[20] Yu WT, Lin JZ, Liu XD, Xie HG, Zhao W, Ma XJ, Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC, Journal of Membrane Science, 2010, 346(2): 296-301
工作照照片：
