交叉學(xué)科
樸豐源
基本情況：
樸豐源，男，博士，教授，博導(dǎo)，現(xiàn)為本院特聘專家。
簡歷介紹：
1983年畢業(yè)于中國醫(yī)科大學(xué)本科，1990年獲中國醫(yī)科大學(xué)衛(wèi)生毒理學(xué)碩士學(xué)位。1991年留學(xué)日本國立三重大學(xué)醫(yī)學(xué)部公眾衛(wèi)生學(xué)教研室，1996年獲醫(yī)學(xué)博士學(xué)位，并在該教研室任助教、講師，2004年破格晉升為副教授。在日本工作期間，曾主持承擔(dān)或分擔(dān)日本文部科學(xué)省、環(huán)境省、三重縣及大學(xué)的多項研究課題，獲得五千多萬日元科研經(jīng)費。2005年作為海外高層次人才引進聘為大連醫(yī)科大學(xué)教授，博士生導(dǎo)師。曾擔(dān)任勞動衛(wèi)生與環(huán)境衛(wèi)生學(xué)教研室主任和省重點學(xué)科帶頭人，大連市分子毒理學(xué)重點實驗室主任。獲得6項國家自燃科學(xué)基金項目，4項日本文部科學(xué)省基金海外項目等，發(fā)表SCI論文100多篇。從2020年1月至今，為大連大學(xué)附屬中山醫(yī)院特聘專家。目前，主要從事環(huán)境化學(xué)物對神經(jīng)和生殖系統(tǒng)的毒作用機制研究；干細胞及其外泌體移植對受損神經(jīng)組織再生修復(fù)的機制研究。
社會兼職及榮譽：
擔(dān)任國際牛磺酸學(xué)會學(xué)術(shù)理事
日本衛(wèi)生學(xué)會委員
日本公眾衛(wèi)生學(xué)會東海地區(qū)委員
曾擔(dān)任第二十一屆國際牛磺酸學(xué)術(shù)大會主席
第72屆日本衛(wèi)生學(xué)會組委會秘書長
日本大氣環(huán)境學(xué)會東海地區(qū)分會秘書長
2010年全國生化/工業(yè)與衛(wèi)生毒理學(xué)學(xué)術(shù)大會主席
兼任國內(nèi)外多個大學(xué)的客座教授
代表性研究成果：
代表性文章：
1. Shuangyue Li, Huai Guan, Yan Zhang, Sheng Li, Kaixin Li, Shuhai Hu, Enjun Zuo, Cong Zhang, Xin Zhang, Guanyu Gong, Ruoyu Wang, Fengyuan Piao*. Bone marrow mesenchymal stem cells promote remyelination in spinal cord by driving oligodendrocyte progenitor cell diferentiation via TNFα/RelB-Hes1 pathway: a rat model study of 2,5-hexanedione-induced neurotoxicity. Stem Cell Res Ther, 2021, 12: 436.
2. Piao F, Chen Y, Yu Li, Shi X, Liu X, Jiang L, Yang G, Gao B and Zhang C. 2,5-hexanedione-induced deregulation of axon-related microRNA expression in rat nerve tissues. Toxicology Letters. 2020, 320: 95-102.
3. Li K, Shi X, Luo M, Inam-U-Llah, Wu P, Zhang M, Zhang C, Li Q, Wang Y and Piao F*. Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway. Exp Cell Res, 2019, 383(2): 111557.
4. Yang Z, Li T, Li S, Wei M, Qi H, Shen B, Chang RC, Le W, Piao F*. Altered expression levels of microRNA-132 and Nurr1 in peripheral blood of Parkinson's disease: a potential disease biomarker. ACS Chem Neurosci. 2019, 10(5): 2243-2249.
5. Hao J, Li S, Shi X, Qian Z, Sun Y, Wang D, Zhou X, Qu H, Hu S, Zuo E, Zhang C, Hou L, Wang Q, Piao F*. Bone marrow mesenchymal stem cells protect against n-hexane-induced neuropathy through beclin 1-independent inhibition of autophagy. Sci Rep. 2018, 8(1): 4516
6. Sun J, Shi X, Li S, Piao F*. 2,5-hexanedione induces bone marrow mesenchymal stem cell apoptosis via inhibition of Akt/Bad signal pathway. J Cell Biochem, 2018, 119(4): 3732-3743
7. Guan H, Li S, Guo Y, Liu X, Yang Y, Guo J, Li S, Zhang C, Shang L, Piao F*. Subchronic Exposure to Arsenic Represses the TH/TRβ1-CaMK IV Signaling Pathway in Mouse Cerebellum, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17(2). pii: E157. doi: 10.3390/ijms17020157.
8. Pan X, Jiang L, Zhong L, Geng C, Jia L, Liu S, Guan H, Yang G, Yao X, Piao F*, Sun X. Arsenic induces apoptosis by the lysosomal-mitochondrial pathway in INS-1 cells，ENVIRONMENTAL TOXICOLOGY，2016, 31 ( 2 ): 133-141.
9. Wang Q, Sun G, Gao C, Feng L, Zhang Y, Hao J, Zuo E, Zhang C, Li S, Piao F*. Bone marrow mesenchymal stem cells attenuate 2,5-hexanedione-induced neuronal apoptosis through a NGF/AKT-dependent pathway. Scientific Reports, 2016, 6: 34715.
10. Cong Zhang, Sheng Li, Yahui Sun, Wei Dong, Fengyuan Piao*, Yongjun Piao, Shuang liu, Huai Guan, Shengbo Yu. Arsenic downregulates gene expression at the postsynaptic density in mouse cerebellum, including genes responsible for long-term potentiation and depression. Toxicol Lett, 2014, 228(3): 260–269
11. Jian Zhang, Xiaohui Liu, Lian Zhao, Shuhai Hu, Sheng Li, Fengyuan Piao*. Subchronic exposure to arsenic disturbed the biogenic amine neurotransmitter level and the mRNA expression of the synthetase in mice brains. Neuroscience, 2013, 41: 2-8
12. Yachen Li, Man Wang, Fengyuan Piao*, Xianghu Wang. Subchronic exposure to arsenic inhibits spermatogenesis and downregulates the expression of Ddx3y in testis and epididymis of mice. Toxicological Sciences, 2012, 128(2)：482–489
13. Shuang Liu, Fengyuan Piao*, Xiance Sun, Lulu Bai, Yan Peng, Yuanxia Zhong, Ning Ma, Wenchang Sun. Arsenic-induced inhibition of hippocampal neurogenesis and its reversibility. NeuroToxicology, 2012, 33(5): 1033-1039
14. Huai Guan, Fengyuan Piao*. Maternal and fetal exposure to uranium in Dalian, China. Acta Obstetricia et Gynecologica Scandinavica, 2011, 90(8): 924-925
15. Huai GUAN, Fengyuan PIAO*, Xiaowei LI, Qiujuan LI, Lei XU and Kazuhito YOKOYAMA. Maternal and Fetal Exposure to Four Carcinogenic metals Associated With Environmental Influencing Factors. Biomedical and Environmental Sciences, 2010, 23: 341-349
16. Yan Hong, Fengyuan Piao* Yufeng Zhao, Sheng Li, Yanyan Wang, Peng Liu. Subchronic exposure to arsenic decreased Sdha expression in the brain of Mice. Neurotoxicology, 2009, 30 (4): 538-543
17. Yanyan Wang, Sheng Li, Fengyuan Piao* YanHong, PengLiu, YufengZhao. Subchronic exposure to arsenic downregulated the expression of Camk4 as an important gene related to the late phase of cerebellar LTD of mice. Neurotoxicology and Teratology, 2009, 31(5): 318-322
18. Fengyuan Piao*, Guang Yang, Qiujuan Li, Jianxin Ye. Taurine and vitamin C prevent RNA damage in brain tissue of mice subchronically exposed to arsenic. Neural Regeneration Research, 2009, 4(11): 838-842
19. Fengyuan Piao*, Kazuhito Yokoyama, Ning Ma, Toru Yamauchi. Subacute toxic effects of zinc on various tissues and organs of rats. Toxicology Letters, 2003, 145: 28-35
20. Fengyuan Piao*, Toru Yamauchi, Ning Ma. The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds. Toxicology Letters, 2003, 143: 65-71
英文專著：
1. Jianmin Hu, Fengyuan Piao（共同主編）, Stephen W. Schaffer, Abdeslem El
Idrissi, Jang-Yen Wu. Taurine 11. Springer Nature Singapore Pte Ltd. 2019, Page: 1-1081.
2. Fengyuan Piao, Shuangyue Li, and Huai Guan. Developmental Arsenic
Exposure Impacts Fetal Programming of the Nervous System in the 1st edition of Handbook of Arsenic Toxicology Edited by S. J. S. Flora. Elsevier. 2015, Page: 1-701.
3. Fengyuan Piao, Shuangyue Li, and Huai Guan. Developmental Arsenic
Exposure Impacts Fetal Programming of the Nervous System in the second edition of Handbook of Arsenic Toxicology Edited by S. J. S. Flora. Elsevier. 2022, Page:
4. Fengyuan Piao. Taurine 11. in Chapter 7 of Toxicology in PART Ⅲ
ENVIRONMENTAL HEALTH of PUBLIC HEALTH & PREVENTIVE MEDICINE Edited by Niu Qiao. McGraw-Hill Education and China Science Publishing & Media Ltd. 2020, Page: 162-341.
5. Fengyuan Piao, Bihu Gao, Xiaolin Yuan1, Shuangyue Li, Cong Zhang, Xiuyan Sun, Qing Zhang. Taurine ameliorates Oxidative Stress in spinal cords of diabetic rats via Keap-Nrf2 in Taurine 12 Edited by Stephen Schaffer. Springer. 2022, Page:
獲獎情況：
1. 大連市科學(xué)技術(shù)二等獎，樸豐源，2012J-2-17-01, 2013年11月，孕期有毒微量元素水平對新生兒發(fā)育影響分析及產(chǎn)后保健指導(dǎo)
招聘博士后的專業(yè)方向要求：
最好是研究神經(jīng)系統(tǒng)和生殖系統(tǒng)的疾病機制或腫瘤誘發(fā)機制以及干細胞再生修復(fù)機制方向的。不過，根據(jù)博士畢業(yè)課題內(nèi)容，如果有切入點，其他專業(yè)方向畢業(yè)的也可以考慮。對應(yīng)聘博士畢業(yè)生，要求具有較熟練的多種分子生物學(xué)檢測技術(shù)和構(gòu)建動物模型和細胞培養(yǎng)技術(shù)，或者具有較強的流行病學(xué)調(diào)查和數(shù)據(jù)統(tǒng)計分析能力。
工作照照片：
