骨外科學(xué)
于曉兵
基本情況：
于曉兵 ，男 ，博士學(xué)位 ，主任醫(yī)師，大連大學(xué)附屬中山醫(yī)院骨八科主任，大連市青年才俊。
簡(jiǎn)歷介紹：
學(xué)科情況：大連大學(xué)附屬中山醫(yī)院骨八科（脊柱二科）成立于2016年3月，現(xiàn)有醫(yī)護(hù)人員13人，床位32張，骨八科（脊柱二科）是一個(gè)年輕、團(tuán)結(jié)向上并富有朝氣的團(tuán)隊(duì)，在科主任于曉兵帶領(lǐng)下，組建了合理的人才梯隊(duì)，技術(shù)力量雄厚，能開(kāi)展各類復(fù)雜的脊柱外傷、退變、腫瘤及側(cè)彎、后凸畸形的治療。目前科室以全脊柱系統(tǒng)治療為發(fā)展方向，同時(shí)以微創(chuàng)的方法治療脊柱骨折的治療為支撐點(diǎn)，以腰椎間盤(pán)突出癥、脊柱骨折等治療為突破點(diǎn)，在脊柱疾病的診治方面均有很高的造詣，尤其擅長(zhǎng)胸腰椎骨折微創(chuàng)手術(shù)。在胸腰椎椎體骨折微創(chuàng)治療上有獨(dú)到的見(jiàn)解和獨(dú)特方法。
研究方向:脊柱相關(guān)疾病研究
主持承擔(dān)項(xiàng)目情況:
1.大連市科技計(jì)劃項(xiàng)目（在研），2021JJ13SN68，大鼠骨髓間充質(zhì)干細(xì)胞來(lái)源的外泌體加載siRNA治療脊髓損傷的機(jī)制研究，10萬(wàn)，主持，負(fù)責(zé)課題設(shè)計(jì)及論文撰寫(xiě)。
2.國(guó)家自然科學(xué)基金面上項(xiàng)目（已結(jié)題）,81371942,髓芯減壓聯(lián)合骨髓基質(zhì)干細(xì)胞移植治療不同類型血液循環(huán)障礙導(dǎo)致的犬早期股骨頭壞死的實(shí)驗(yàn)研究,2014/1-2017/12,70萬(wàn),主要參加人員，負(fù)責(zé)標(biāo)本檢測(cè)及論文撰寫(xiě)。
3.國(guó)家自然科學(xué)基金面上項(xiàng)目（已結(jié)題）,81201398,壓控下 BMMSCs/PRF 雙層復(fù)合體 治療塌陷后股骨頭壞死軟骨損傷的機(jī)制研究,2013/1-2015/12,23 萬(wàn)，主要參加人員，負(fù)責(zé)標(biāo)本檢測(cè)及論文撰寫(xiě)。
4.大連市衛(wèi)生局課題（已結(jié)題）,數(shù)字減影血管造影術(shù)指導(dǎo)下股骨頭壞死微創(chuàng)治療的實(shí)驗(yàn)研究,2014/1-2014/12,2 萬(wàn),主持，負(fù)責(zé)標(biāo)本檢測(cè)及論文撰寫(xiě)。
5.遼寧省自然基金（已結(jié)題）:(2015020669)在激素性兔股骨頭壞死中 Akt/IGF-1激活Wnt/β-catenin信號(hào)通路活性的機(jī)制究,2015/10-2017/12,20萬(wàn),主持，負(fù)責(zé)課題設(shè)計(jì)及論文撰寫(xiě)。
6.大連市衛(wèi)生局課題（已結(jié)題），不同應(yīng)力對(duì)大鼠股骨頭壞死自身修復(fù)過(guò)程中胰島素 樣生長(zhǎng)因子-1 表達(dá)的影響,2015/1-2016/12,2萬(wàn)，主持，負(fù)責(zé)課題設(shè)計(jì)及論文撰寫(xiě)。
7.大連大學(xué)博士啟動(dòng)基金（已結(jié)題），不同應(yīng)力對(duì)大鼠股骨頭壞死自身修復(fù)過(guò)程中胰 島素樣生長(zhǎng)因子-1表達(dá)的影響，2015/1-2016/12，1萬(wàn)，主持，負(fù)責(zé)課題設(shè)計(jì)及論文撰寫(xiě)。
8.博士后課題（已結(jié)題），Mg/PLLA 生物可吸收接骨板的制備及生物學(xué)性能研究，2015/12-2017/12，21萬(wàn)，主持，負(fù)責(zé)課題設(shè)計(jì)及論文撰寫(xiě)。
社會(huì)兼職及榮譽(yù)：
中國(guó)醫(yī)師協(xié)會(huì)骨科醫(yī)師分會(huì)第五屆委員會(huì)脊柱創(chuàng)傷學(xué)組委員
中國(guó)醫(yī)師協(xié)會(huì)顯微外科分會(huì)神經(jīng)脊柱專委會(huì)委員
代表性研究成果：
代表性文章：
1.Huang W, Lin M, Yang C, Wang F, Zhang M, Gao J, Yu X. Rat Bone Mesenchymal Stem Cell-Derived Exosomes Loaded with miR-494 Promoting Neurofilament Regeneration and Behavioral Function Recovery after Spinal Cord Injury. Oxid Med Cell Longev. 2021 Oct 1;2021:1634917. doi: 10.1155/2021/1634917. PMID: 34635862; PMCID: PMC8501401.
2.Lin M, Qu M, Huang W, Liu T, Duan R, Yuan Y, et al. Clinical effectiveness of percutaneous vertebroplasty in conjunction with postoperative radiotherapy in the treatment of spinal metastases[J]. Journal of Cancer Research and Clinical Oncology, 2021, 147(3): 835-844.
3.Huang W, Qu M, Li L, Liu T, Lin M, Yu X. SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats[J]. Stem Cell Res Ther, 2021, 12(1): 334.
4.Duan R, Qu M, Yuan Y, Lin M, Liu T, Huang W, et al. Clinical Benefit of Rehabilitation Training in Spinal Cord Injury: A Systematic Review and Meta-Analysis[J]. Spine (Phila Pa 1976), 2021, 46(6): E398-E410.
5.Wang T N, Wu B L, Duan R M, Yuan Y S, Qu M J, Zhang S, et al. Treatment of Thoracolumbar Fractures Through Different Short Segment Pedicle Screw Fixation Techniques: A Finite Element Analysis[J]. Orthop Surg, 2020, 12(2): 601-608.
6.Huang W, Liu T, Duan R, Yuan Y, Qu M, Zhang M, et al. Primary multiple angiosarcoma of vertebra: A case report[J]. Medicine (Baltimore), 2020, 99(50): e23587.
7.Yuan Y, Yu X. Therapeutic effects of rehabilitation training methods on spinal cord injury: a meta-analysis[J]. The Lancet, 2019, 394: S27-.
8.Yuan Y, Duan R, Wu B, Huang W, Zhang X, Qu M, et al. Gene expression profiles and bioinformatics analysis of insulin-like growth factor-1 promotion of osteogenic differentiation[J]. Mol Genet Genomic Med, 2019, 7(10): e00921.
9.Yu X, Zhang S, Zhao D, Zhang X, Xia C, Wang T, et al. SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494[J]. Int J Mol Med, 2019, 43(4): 1758-1768.
10.Yu X, Liu T, Zhao D, Yang K, Zhang X, Zhang M, et al. Efficacy and Safety of Pregabalin in Neuropathic Pain Followed Spinal Cord Injury: A Review and Meta-Analysis of Randomized Controlled Trials[J]. Clin J Pain, 2019, 35(3): 272-278.
11.Yu X, Huang W, Zhao D, Yang K, Tan L, Zhang X, et al. Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study[J]. Colloids Surf B Biointerfaces, 2019, 174: 280-290.
12.Xiaobing Yu,MD*Tienan Wang,MD Baolin Wu,MD Dewei Zhao,MD Ke Yang,MD Xiuzhi Zhang,MD Meng Zhang,MD Shuo Zhang,MD Wei Huang,MD Tao Liu,MD Weiting Yu,MD Junlei Li,MD Identification of gene co-expression modules, hub genes and pathways related to spinal cord injury using integrated bioinformatics methods.JOURNAL OF CELLULAR BIOCHEMISTRY .IF:2.95 (accepted in 2018)
13.Xiaobing Yu,MD Wei Huang,MD Lili Tan ,MD Xiuzhi Zhang,MD Junlei Li,MD Meng Zhang,MD Shuo Zhang,MD Tao Liu,MD Baolin Wu,MD Dewei Zhao,MD* Ke Yang,MD*.Study of engineered low-modulus Mg/PLLA composites as potential feasible orthopaedic implants: An in vitro and in vivo study.Colloids and Surfaces B: Biointerfaces.IF:3.99(2018)
14.Yu Xiaobing*,Zhang Shuo, Zhao Dewei, Zhang Xiuzhi, Xia Chongjun, Wang Tienan,Zhang Meng, Liu Tao, Huang Wei, Wu Baolin. SIRT1 inhibits apoptosis of spinal cord injury in vivo and vitro model through microRNA-494.International journal of molecular medicine.IF:2.78(accepted in 2018)
15.Xiaobing Yu,MD*，Tao Liu,MD，Dewei Zhao,MD，Ke Yang,MD，Xiuzhi Zhang,MD， Meng Zhang,MD，Shuo Zhang,MD，Wei Huang,MD，Baolin Wu,MD，Junlei Li,MD
.Efficacy and safety of pregabalin in neuropathic pain followed spinal cord injury: a review and meta-analysis of randomized controlled trials.The Clinical Journal of Pain.IF=3.209(2018)
16.Xiaobing Yu, MD*Wei Huang MD , Shuo Zhang MD , Tao Liu MD, Baolin Wu MD , Ruimeng Duan MD ,Yashuai Yuan MD ,Mingjia Qu MD ,Xiuzhi Zhang MD,Meng Zhang MD ,Depeng Shang MD .Mesenchymal Stem Cells-Derived Exosomes loaded with siRNA for Spinal Cord Injury Treatment in rat.Journal Basic & Clinical Pharmacology & Toxicology.IF:2.65(2018)
17. Xiaobing Yu MD ,Yashuai Yuan MD , Ruimeng Duan MD , Mingjia Qu MD ,Shuo Zhang MM , WeiHuang MD ,Tao Liu MD ,Baolin Wu MD ,Meng Zhang MD , Depeng Shang MD , Dewei Zhao MD*.An experimental study of the effects of different stress stimuli on the expression of insulin-like growth factor -1 in the repair of femoral head necrosis.Journal Basic & Clinical Pharmacology & Toxicology.IF:2.65(2018)
18. Xiaobing Yu, MD* Shuo Zhang,Dewei Zhao MD,Xiuzhi Zhang MD,Jianchuan Wang,Chongjun Xia,Tienan Wang.The Role of Original Hematoma in Accelerating the Fracture Healing for the Treatment of Intertrochanteric Fracture.Journal Basic & Clinical Pharmacology & Toxicology.IF:2.65( 2018)
19.Yu XB, Zhao DW*, Zhong SZ, Liu BY, Wang BJ, Liu YP, Zhang Y, Cui DP, Fu DP, Xie H. Prospective and comparative analysis of internal fixation of femoral neck fractures with or without vascularized iliac graft in young adults. Orthopedics. 2013 Feb 1;36(2):e132-8. doi: 10.3928/01477447-20130122-12.
20.Yu X, Zhao D, Huang S, Wang B, Zhang X, Wang W, Wei X. Biodegradable magnesium screws and vascularized iliac grafting for displaced femoral neck fracture in young adults. BMC Musculoskelet Disord. 2015 Nov 2;16(1):329.
專利及成果轉(zhuǎn)化情況：
1.一種關(guān)節(jié)鏡手術(shù)半月板縫合器
2.一種生物材料拼接的脊柱椎間融合器
3.一種膠原基可降解脊柱融合器及其制備方案
出版論著:
1.《股骨頭缺血性壞死的微創(chuàng)治療技術(shù)》人民衛(wèi)生出版社
2.《兒童股骨頭缺血性壞死的診斷與治療》，人民衛(wèi)生出版社
3.《骨科進(jìn)修醫(yī)師指導(dǎo)手冊(cè)》，遼寧科技出版社
4.《股骨頭缺血性壞死的修復(fù)與再造》（第2版），人民衛(wèi)生出版社
5.《現(xiàn)代骨科學(xué)》，科學(xué)技術(shù)文獻(xiàn)出版社
獲獎(jiǎng)情況:
教育部科技進(jìn)步一等獎(jiǎng)1項(xiàng)，遼寧省科技進(jìn)步獎(jiǎng)一等獎(jiǎng)1項(xiàng),大連市科學(xué)技術(shù)獎(jiǎng)二等獎(jiǎng)1項(xiàng)，獲2015年大連市青年科技獎(jiǎng)，獲2015年中國(guó)醫(yī)師協(xié)會(huì)骨科分會(huì)授予的優(yōu)秀青年醫(yī)師獎(jiǎng)。
招聘博士后的專業(yè)方向要求：
生物醫(yī)藥類：脊柱相關(guān)疾病研究
醫(yī)學(xué)相關(guān)類：力學(xué)、材料科學(xué)與工程等
工作照照片：
